Laboratory of Aging and Neurodegeneration


Recent Publications

Sepulveda J, Kim JY, Binder J, Vicini S, Rebeck GW, 2024, “APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Ab, through P2RY12,” Mol Neurodegen .

Pandit H, Jones N, Rebeck GW, 2024, “Obesity affects brain cortex gene expression in an APOE genotype and sex dependent manner,” Int J Obes .

Demby T*, Gross PS*, Mandelblatt J, Huang JK, Rebeck GW, 2023, “The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype,” Exp Neurol 371:114609

Galvano E*, Pandit H*, Sepulveda J, Ng CAS, Becher MK, Mandelblatt JS, Van Dyk K#, Rebeck GW#, 2023, “Behavioral and transcriptomic effects of the cancer treatment Tamoxifen in mice,” Frontiers Neurosci 17:1068334. PMC9951777

Ng CAS, Biran LP, Galvano E, Mandelblatt J, Vicini S, Rebeck GW, 2022, “Chemotherapy promotes astrocytic response to Ab deposition, but not Ab levels, in a mouse model of amyloid and APOE,” Neurobiol Dis 175:105915. PMC9794416.

Sepulveda J, Luo N, Nelson M, Ng CAS, Rebeck GW, 2022, “Independent APOE4 knock-in mouse models display reduced brain APOE protein, altered neuroinflammation, and simplification of dendritic spines,” J Neurochem 163:247-259. PMC9613529.

Jones NS, Watson KQ, Rebeck GW, 2021, “High fat diet increases gliosis and immediate early gene expression in APOE3 mice, but not APOE4 mice,” J NeuroInflammation 2021 Sep 18;18(1):214.  PMC8449905

Lanfranco MF, Sepulveda J, Kopetsky G, Rebeck GW, 2021, “Expression and secretion of APOE isoforms in astrocytes and microglia during inflammation,” Glia 69:1478-1493. PMC8717762

Van Dyk K, Zhou X, Small BJ, Ahn J, Zhai W, Ahles T, Graham D, Jacobsen PB, Jim H, McDonald BC, Holohan KN, Patel SK, Rebeck GW, Root JC, Saykin AJ, Cohen HJ, Mandelblatt JS, Carroll JE, 2021, “Protective Effects of APOE ε2 Genotype on Cognition in Older Breast Cancer Survivors: The Thinking and Living with Cancer Study,” JNCI Cancer Spectr 5(2):pkab013. PMC7962698. 

Yang FN, Bronshteyn M, Flowers SA, Dawson M, Kumar P, Rebeck GW, Turner RS, Moore DJ, Ellis RJ, Jiang X, 2021, “Low CD4 nadir exacerbates the impacts of APOE e4 on functional connectivity and memory in adults with HIV,” AIDS 35:727-736. PMC8318747


Demby TC, Rodriguez O, McCarthy CW, Lee YC, Albanese C, Mandelblatt J, Rebeck GW, 2020, “A mouse model of chemotherapy-related cognitive impairments integrating the risk factors of aging and APOE4genotype,” Behav Brain Res 384:112534. PMC7082850.


Flowers SA, Grant OC, Woods RJ, Rebeck GW, 2020, “O-glycosylation on cerebrospinal fluid and plasma Apolipoprotein E differs in the lipid binding domain,” Glycobiology 30:74-85. PMC7335482.


Fernandez HR, Varma A, Flowers SA, Rebeck GW, 2020, “Cancer chemotherapy related cognitive impairment and the impact of the Alzheimer’s disease risk factor APOE,” Cancers 12:3842. PMC7766535.


Lanfranco MF, Ng CA, Rebeck GW, 2020, “ApoE lipidation as a therapeutic target in Alzheimer’s disease,” International Journal of Molecular Sciences, Intl J Mol Sci 21:6336. PMC7503657. 


Flowers SA and Rebeck GW, 2020, “APOE in the normal brain,” Neurobiol Disease 136:104724. PMC7002287.


Shinohara M, Kanekiyo T, Tachibana M, Kurti A, Shinohara M, Fu Y, Zhao J, Han X, Sullivan PM, Rebeck GW, Fryer JD, Heckman MG, Bu G, 2020, “APOE2 is associated with longevity independent of Alzheimer’s disease,” eLife 9:e62199. PMC7588231.


Jones NS, Watson KQ, Rebeck GW, 2019, “Metabolic disturbances of a high fat diet are dependent on APOE genotype and sex,” eNeuro 6(5). PMC6795556.

Speidell AP, Demby T, Lee Y, Rodriguez O, Albanese C, Mandelblatt J, Rebeck GW, 2019, “Development of a human APOE knock-in mouse model for study of cognitive function after cancer chemotherapy,” Neurotox Res 35:291-303. PMC6333492.

Jones NS and Rebeck GW, 2018, “The synergistic effects of APOE genotype and obesity on Alzheimer's Disease risk,” International Journal of Molecular Sciences 20(1). PMC6337558.