Featured Works

Mouse models of Anti-AB immunotherapies

Recent Publications

Rebeck GW, Shautidze G, Sepulveda J, Healey GS, Narayan P. Plasma membrane remodeling during microglial activation: a hypothesis linking microglial shape and lipid droplet formation. Glia. 2026 Aug;74(8):e70193. doi: 10.1002/glia.70193.

Hughes E, Barton K, Rizvi D, Dial K, Wang XX, Myakala K, Harris BT, Rebeck GW, Levi M. Nicotinamide Riboside (NR) Supplementation Exerts Neuroprotective Effects in db/db Mouse Model of Type 2 Diabetes. J Mol Neurosci. 2026 Apr 27;76(2). doi: 10.1007/s12031-026-02499-9. PubMed PMID: 42043487; PubMed Central PMCID: PMC13200791.

Luo N, Pandit H, Kalra S, Tran E, Mandelblatt J, Vicini S, Rebeck GW. APOE4 and doxorubicin impair inhibitory interneuron function and homeostatic regulation in the entorhinal cortex. PLoS One. 2026;21(3):e0343276. doi: 10.1371/journal.pone.0343276. eCollection 2026. PubMed PMID: 41886471; PubMed Central PMCID: PMC13020844.

Stephenson RA, Sepulveda J, Johnson KR, Lita A, Gopalakrishnan J, Acri DJ, Beilina A, Cheng L, Yang LG, Root JT, Ward ME, Combs C, Skarnes WC, Cookson MR, Shih HY, Larion M, Rebeck GW, Narayan PS. Triglyceride metabolism controls inflammation and microglial phenotypes associated with APOE4. Cell Rep. 2025 Jul 22;44(7):115961. doi: 10.1016/j.celrep.2025.115961. Epub 2025 Jul 10. PubMed PMID: 40644302; PubMed Central PMCID: PMC12410147.

Pikus P, Turner RS, Rebeck GW. Mouse models of Anti-Aβ immunotherapies. Mol Neurodegener. 2025 May 13;20(1):57. doi: 10.1186/s13024-025-00836-x. Review. PubMed PMID: 40361247; PubMed Central PMCID: PMC12076828.

Ng CAS, Pedus M, Lee MF, Kromer LF, Mandelblatt J, Rebeck GW. The chemotherapy agent doxorubicin induces CNS expression of Ascl1, a regulator of adult neurogenesis and differentiation. Sci Rep. 2025 Mar 21;15(1):9725. doi: 10.1038/s41598-025-94400-8. PubMed PMID: 4011

Mandelblatt JS, Antoni MH, Bethea TN, Cole S, Hudson BI, Penedo FJ, Ramirez AG, Rebeck GW, Sarkar S, Schwartz AG, Sloan EK, Zheng YL, Carroll JE, Sedrak MS. Gerotherapeutics: aging mechanism-based pharmaceutical and behavioral interventions to reduce cancer racial and ethnic disparities. J Natl Cancer Inst. 2025 Mar 1;117(3):406-422. doi: 10.1093/jnci/djae211. Review. PubMed PMID: 39196709; PubMed Central PMCID: PMC11884862.

Torres ERS, Rebeck GW, Nuriel T. Editorial: APOE4-associated heterogeneity in the pathogenesis of Alzheimer's disease. Front Aging Neurosci. 2024;16:1509307. doi: 10.3389/fnagi.2024.1509307. eCollection 2024. PubMed PMID: 39629475; PubMed Central PMCID: PMC11613161.

Mandelblatt J, Dage JL, Zhou X, Small BJ, Ahles TA, Ahn J, Artese A, Bethea TN, Breen EC, Carroll JE, Cohen HJ, Extermann M, Graham D, Claudine I, Jim HSL, McDonald BC, Nakamura ZM, Patel SK, Rebeck GW, Rentscher KE, Root JC, Russ KA, Tometich DB, Turner RS, Van Dyk K, Zhai W, Huang LW, Saykin AJ. Alzheimer disease-related biomarkers and cancer-related cognitive decline: the Thinking and Living with Cancer study. J Natl Cancer Inst. 2024 Sep 1;116(9):1495-1507. doi: 10.1093/jnci/djae113. PubMed PMID: 38788675; PubMed Central PMCID: PMC11378315.

Sepulveda J, Kim JY, Binder J, Vicini S, Rebeck GW. APOE4 genotype and aging impair injury-induced microglial behavior in brain slices, including toward Aβ, through P2RY12. Mol Neurodegener. 2024 Mar 11;19(1):24. doi: 10.1186/s13024-024-00714-y. PubMed PMID: 38468308; PubMed Central PMCID: PMC10929239.

Pandit H, Jones NS, Rebeck GW. Obesity affects brain cortex gene expression in an APOE genotype and sex dependent manner. Int J Obes (Lond). 2024 Jun;48(6):841-848. doi: 10.1038/s41366-024-01481-y. Epub 2024 Mar 7. PubMed PMID: 38454009; PubMed Central PMCID: PMC11379128.

Demby T, Gross PS, Mandelblatt J, Huang JK, Rebeck GW. The chemotherapeutic agent doxorubicin induces brain senescence, with modulation by APOE genotype. Exp Neurol. 2024 Jan;371:114609. doi: 10.1016/j.expneurol.2023.114609. Epub 2023 Nov 7. PubMed PMID: 37944881; PubMed Central PMCID: PMC11302516.

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